(cannabis plant, has neuroprotective effects.
Related: Juicing Raw Cannabis Leaves, The Amazing Health Benefits
Source - Humans Are Free
by Mary Biles, Oct 1st, 2017
Apart from flight inwards the confront of the belief that cannabis damages encephalon cells, why should nosotros aid whether something is neuroprotective or not?
The decease of encephalon cells is a natural component division of the ageing process. Cells kicking the bucket off together with the trunk is also capable of making novel ones through neurogenesis.
But the older nosotros get, the to a greater extent than susceptible nosotros acquire to ‘inappropriate prison theatre cellular telephone death’ through traumatic injury, environmental toxins, cardiovascular disorders, infectious agents, or genetic diseases.
That’s why scientists are researching neuroprotective drugs to bound the harm caused to encephalon cells after acuate events such equally strokes, to wearisome downwards the progression of neurodegenerative diseases, together with to fifty-fifty foreclose unnecessary prison theatre cellular telephone decease from happening inwards the get-go place.
Different molecules inwards the cannabis flora – called cannabinoids – are beingness investigated for their neuroprotective action, but inwards companionship to empathize why, let’s get-go bring a await at why encephalon cells kicking the bucket off inwards the get-go place.
What causes encephalon prison theatre cellular telephone death?
1. Oxidative stress
Just beingness survive together with burning liberate energy creates oxidative stress – harm caused past times gratis radicals which the trunk cannot remove.
Dr Joseph Mercola describes the final result a variety of ‘biological rusting’ where at that spot is equally good much oxygen inwards our tissues leading to a host of historic menstruation related diseases such equally chronic inflammation, cancer, neurodegenerative diseases similar Alzheimer’s together with Parkinson’s, autoimmune conditions, pump disease, together with strokes.
2. Excitotoxicity
Too much activity inwards the encephalon tin get neurons to kicking the bucket off. This is to a greater extent than oft than non attributed to over stimulation past times the neurotransmitter glutamate, a province of affairs commonly constitute inwards many neurodegenerative diseases together with next strokes.
3. Inflammatory changes
Inflammation is commonly a sign of the immune organization going virtually its chore of cleaning upwardly after an injury or dealing alongside a unusual invasion such equally a bacteria or a virus. However, equally good much inflammation tin get prison theatre cellular telephone death.
According to Gary Wenk, PhD, professor of neuroscience, immunology together with medical genetics at Ohio State University, ‘PET imaging studies of humans receive got shown that after historic menstruation 30 the encephalon gradually displays increasing evidence of inflammation.
With advancing age, encephalon inflammation continues to worsen leading to a reject inwards the production of novel neurons, called neurogenesis, that are of import for making novel memories’.
4. Iron accumulation
Scientists believe excess atomic number 26 inwards the encephalon plays a role inwards degenerative diseases such equally Alzheimer’s, Parkinson’s together with amyotrophic lateral sclerosis (ALS). This atomic number 26 build-up is may survive component division of the cycle of excitotoxicity together with encephalon prison theatre cellular telephone death.
5. Brain proteins
While much is withal to survive learned virtually diseases such equally Alzheimer’s, scientists at nowadays know that a mutual element is the develop upwardly of proteins called beta-amyloid which shape into plaques. It is idea these plaques may block cell-to-cell signalling at synapses together with practise excess inflammation equally the immune organization kicks inwards to assault the affected cells.
Influenza A virus subtype H5N1 poly peptide called tumor necrosis element (TNF) has also been constitute acquaint inwards neurodegenerative diseases, together with is farther associated alongside excitotoxicity together with high levels of glutamate.
With all these pathological changes occurring inwards weather related to a degeneration inwards the brain, it would brand feel that scientists are looking for a pharmaceutical magic bullet that tin address each together with every 1 of them. But what if they didn’t receive got to await whatever farther than the cannabis plant?
THCA an exciting neuroprotective prospective?
Let’s acquire dorsum to the most recent regain regarding the neuroprotective qualities of THCA. First things first, THCA is the acid precursor of THC, the most good known together with to a greater extent than oft than non abundant chemical compound inwards cannabis.
If y'all picked the leaves together with flowers similar a shot off a cannabis plant, you’d regain barely whatever THC, what you’d acquire instead is enough of THCA. That’s because inwards companionship to acquire THC, THCA must locomote through approximately variety of estrus procedure or decarboxylation.
Comparatively petty query has been done on THCA. However, scientists practise know is that it has no psychoactive final result together with appears to survive anti-inflammatory, anti-emetic together with shows approximately anecdotal success inwards reducing seizures.
This latest query adds neuroprotection to the list. It studied the final result of the raw cannabinoid on cells together with mice modified to elicit the symptoms of Huntington’s disease.
In the prison theatre cellular telephone cultures they constitute THCA caused an increase inwards mitochondrial majority equally good equally reducing prison theatre cellular telephone toxicity, piece inwards the mice, THCA improved their Huntington’s related restricted movement, prevented striatal degeneration together with reduced the inflammation caused past times the disease.
Scientists noticed that these effects were elicited independently of the endocannabinoid system, concluding:
“THCA shows strong neuroprotective activity, worth consideration for the handling of Huntington’s Disease together with mayhap other neurodegenerative together with neuroinflammatory diseases.”
While this farther strengthens the growing wellness tendency towards consuming raw cannabis, inwards a laboratory setting acid cannabinoids tin survive quite difficult to piece of occupation alongside due to their instability together with transformation into their decarboxylated versions.
What virtually the other cannabinoids?
One of the keen mystifying contradictions inwards the earth of medical cannabis is how on the 1 manus it is a schedule 1 banned meat deemed bereft of whatever therapeutic value together with yet the the States Federal Government holds a patent for the plant’s principal cannabinoids based on their antioxidant together with neuroprotective effects.
the States Patent US6630507 states how cannabinoids are:
“… useful inwards the handling together with prophylaxis of broad diverseness of oxidation associated diseases, such equally ischemic, age-related, inflammatory together with autoimmune diseases.
“The cannabinoids are constitute to receive got detail application equally neuroprotectants, for illustration inwards limiting neurological harm next ischemic insults, such equally stroke together with trauma, or inwards the handling of neurodegenerative diseases, such equally Alzheimer’s disease, Parkinson’s illness together with HIV dementia.”
Contradiction aside, this world proclamation based on obvious vested fiscal interests is hardly surprising when 1 considers that cannabinoids similar THC together with CBD furnish a potentially unique multipronged approach to preventing, protecting together with limiting the harm caused past times strokes together with neurodegenerative disease.
One of the primal reasons beingness that THC together with CBD equally considered powerful antioxidants, on a par alongside vitamins C together with E. Studies receive got constitute that cannabinoids tin cut down the excitotoxicity associated alongside equally good much glutamate production equally good equally protecting encephalon cells against the harm caused past times excessive iron.
Not solely that, but cannabinoids receive got been constitute to promote the holy grail of the salubrious ageing brain, neurogenesis, or the growth of novel encephalon cells.
Research has shown the direction of flora cannabinoids promoted hippocampal neurogenesis – novel prison theatre cellular telephone growth inwards the part of the encephalon associated both alongside retention together with learning.
Cannabinoids receive got also shown hope inwards reducing the neuro-inflammation constitute inwards rodents injected alongside the amyloid beta poly peptide which equally discussed earlier tin Pb to neuronal prison theatre cellular telephone decease inwards Alzheimer’s.
And finally, CBD inwards detail is idea to bound the harm caused to the encephalon after a stroke past times blocking the neurotransmitter, glutamate.
To pose this into perspective, thence far most neuroprotective drugs nether query are based on unmarried therapeutic targets. They aim to protect the encephalon past times doing 1 affair at a time.
Explains Javier Fernandez Ruiz, Professor of Molecular Biology specialising inwards neurodegenerative diseases at the Complutense University inwards Madrid:
“This is 1 of the keen advantages of cannabinoids. They receive got a real broad spectrum together with are extremely varied compared to other neuroprotective agents that receive got been researched until now. These receive got consisted of anti-excitotoxins to improve the glutamate homeostasis, antioxidants or anti-inflammatories.
“But what nosotros know is that the diverse stimuli that get prison theatre cellular telephone decease piece of occupation together. In other words, where at that spot is excitotoxicity at that spot is oxidative stress, the proteins acquire oxidized, they lose their function, they shape together to brand plaques, which causes an inflammatory response.
“We are non going to stop neurodegenerative diseases unless nosotros receive got neuroprotective strategies that piece of occupation together past times reducing inflammation piece at the same fourth dimension beingness antioxidants, inducing autophagy inwards companionship to eliminate the poly peptide develop up, together with returning the glutamate levels to normal.
“This is something that cannabinoids tin do, either 1 cannabinoid or a number of cannabinoids together.”
So far, the land of neuroprotective pharmacological drugs is inwards its infancy, both inwards medical cannabis derivative query together with farther afield.
However, the race is on to come across who tin crevice the puzzle together with regain the combination of cannabinoids that volition non solely wearisome downwards neurodegenerative disease, but maybe fifty-fifty foreclose us from getting them inwards the get-go place.
1. Oxidative stress
Just beingness survive together with burning liberate energy creates oxidative stress – harm caused past times gratis radicals which the trunk cannot remove.
Dr Joseph Mercola describes the final result a variety of ‘biological rusting’ where at that spot is equally good much oxygen inwards our tissues leading to a host of historic menstruation related diseases such equally chronic inflammation, cancer, neurodegenerative diseases similar Alzheimer’s together with Parkinson’s, autoimmune conditions, pump disease, together with strokes.
2. Excitotoxicity
Too much activity inwards the encephalon tin get neurons to kicking the bucket off. This is to a greater extent than oft than non attributed to over stimulation past times the neurotransmitter glutamate, a province of affairs commonly constitute inwards many neurodegenerative diseases together with next strokes.
3. Inflammatory changes
Inflammation is commonly a sign of the immune organization going virtually its chore of cleaning upwardly after an injury or dealing alongside a unusual invasion such equally a bacteria or a virus. However, equally good much inflammation tin get prison theatre cellular telephone death.
According to Gary Wenk, PhD, professor of neuroscience, immunology together with medical genetics at Ohio State University, ‘PET imaging studies of humans receive got shown that after historic menstruation 30 the encephalon gradually displays increasing evidence of inflammation.
With advancing age, encephalon inflammation continues to worsen leading to a reject inwards the production of novel neurons, called neurogenesis, that are of import for making novel memories’.
4. Iron accumulation
Scientists believe excess atomic number 26 inwards the encephalon plays a role inwards degenerative diseases such equally Alzheimer’s, Parkinson’s together with amyotrophic lateral sclerosis (ALS). This atomic number 26 build-up is may survive component division of the cycle of excitotoxicity together with encephalon prison theatre cellular telephone death.
5. Brain proteins
While much is withal to survive learned virtually diseases such equally Alzheimer’s, scientists at nowadays know that a mutual element is the develop upwardly of proteins called beta-amyloid which shape into plaques. It is idea these plaques may block cell-to-cell signalling at synapses together with practise excess inflammation equally the immune organization kicks inwards to assault the affected cells.
Influenza A virus subtype H5N1 poly peptide called tumor necrosis element (TNF) has also been constitute acquaint inwards neurodegenerative diseases, together with is farther associated alongside excitotoxicity together with high levels of glutamate.
With all these pathological changes occurring inwards weather related to a degeneration inwards the brain, it would brand feel that scientists are looking for a pharmaceutical magic bullet that tin address each together with every 1 of them. But what if they didn’t receive got to await whatever farther than the cannabis plant?
THCA an exciting neuroprotective prospective?
Let’s acquire dorsum to the most recent regain regarding the neuroprotective qualities of THCA. First things first, THCA is the acid precursor of THC, the most good known together with to a greater extent than oft than non abundant chemical compound inwards cannabis.
If y'all picked the leaves together with flowers similar a shot off a cannabis plant, you’d regain barely whatever THC, what you’d acquire instead is enough of THCA. That’s because inwards companionship to acquire THC, THCA must locomote through approximately variety of estrus procedure or decarboxylation.
Comparatively petty query has been done on THCA. However, scientists practise know is that it has no psychoactive final result together with appears to survive anti-inflammatory, anti-emetic together with shows approximately anecdotal success inwards reducing seizures.
This latest query adds neuroprotection to the list. It studied the final result of the raw cannabinoid on cells together with mice modified to elicit the symptoms of Huntington’s disease.
In the prison theatre cellular telephone cultures they constitute THCA caused an increase inwards mitochondrial majority equally good equally reducing prison theatre cellular telephone toxicity, piece inwards the mice, THCA improved their Huntington’s related restricted movement, prevented striatal degeneration together with reduced the inflammation caused past times the disease.
Scientists noticed that these effects were elicited independently of the endocannabinoid system, concluding:
“THCA shows strong neuroprotective activity, worth consideration for the handling of Huntington’s Disease together with mayhap other neurodegenerative together with neuroinflammatory diseases.”
While this farther strengthens the growing wellness tendency towards consuming raw cannabis, inwards a laboratory setting acid cannabinoids tin survive quite difficult to piece of occupation alongside due to their instability together with transformation into their decarboxylated versions.
What virtually the other cannabinoids?
One of the keen mystifying contradictions inwards the earth of medical cannabis is how on the 1 manus it is a schedule 1 banned meat deemed bereft of whatever therapeutic value together with yet the the States Federal Government holds a patent for the plant’s principal cannabinoids based on their antioxidant together with neuroprotective effects.
the States Patent US6630507 states how cannabinoids are:
“… useful inwards the handling together with prophylaxis of broad diverseness of oxidation associated diseases, such equally ischemic, age-related, inflammatory together with autoimmune diseases.
“The cannabinoids are constitute to receive got detail application equally neuroprotectants, for illustration inwards limiting neurological harm next ischemic insults, such equally stroke together with trauma, or inwards the handling of neurodegenerative diseases, such equally Alzheimer’s disease, Parkinson’s illness together with HIV dementia.”
Contradiction aside, this world proclamation based on obvious vested fiscal interests is hardly surprising when 1 considers that cannabinoids similar THC together with CBD furnish a potentially unique multipronged approach to preventing, protecting together with limiting the harm caused past times strokes together with neurodegenerative disease.
One of the primal reasons beingness that THC together with CBD equally considered powerful antioxidants, on a par alongside vitamins C together with E. Studies receive got constitute that cannabinoids tin cut down the excitotoxicity associated alongside equally good much glutamate production equally good equally protecting encephalon cells against the harm caused past times excessive iron.
Not solely that, but cannabinoids receive got been constitute to promote the holy grail of the salubrious ageing brain, neurogenesis, or the growth of novel encephalon cells.
Research has shown the direction of flora cannabinoids promoted hippocampal neurogenesis – novel prison theatre cellular telephone growth inwards the part of the encephalon associated both alongside retention together with learning.
Cannabinoids receive got also shown hope inwards reducing the neuro-inflammation constitute inwards rodents injected alongside the amyloid beta poly peptide which equally discussed earlier tin Pb to neuronal prison theatre cellular telephone decease inwards Alzheimer’s.
And finally, CBD inwards detail is idea to bound the harm caused to the encephalon after a stroke past times blocking the neurotransmitter, glutamate.
To pose this into perspective, thence far most neuroprotective drugs nether query are based on unmarried therapeutic targets. They aim to protect the encephalon past times doing 1 affair at a time.
Explains Javier Fernandez Ruiz, Professor of Molecular Biology specialising inwards neurodegenerative diseases at the Complutense University inwards Madrid:
“This is 1 of the keen advantages of cannabinoids. They receive got a real broad spectrum together with are extremely varied compared to other neuroprotective agents that receive got been researched until now. These receive got consisted of anti-excitotoxins to improve the glutamate homeostasis, antioxidants or anti-inflammatories.
“But what nosotros know is that the diverse stimuli that get prison theatre cellular telephone decease piece of occupation together. In other words, where at that spot is excitotoxicity at that spot is oxidative stress, the proteins acquire oxidized, they lose their function, they shape together to brand plaques, which causes an inflammatory response.
“We are non going to stop neurodegenerative diseases unless nosotros receive got neuroprotective strategies that piece of occupation together past times reducing inflammation piece at the same fourth dimension beingness antioxidants, inducing autophagy inwards companionship to eliminate the poly peptide develop up, together with returning the glutamate levels to normal.
“This is something that cannabinoids tin do, either 1 cannabinoid or a number of cannabinoids together.”
So far, the land of neuroprotective pharmacological drugs is inwards its infancy, both inwards medical cannabis derivative query together with farther afield.
However, the race is on to come across who tin crevice the puzzle together with regain the combination of cannabinoids that volition non solely wearisome downwards neurodegenerative disease, but maybe fifty-fifty foreclose us from getting them inwards the get-go place.
About the Author
Mary Biles is a British freelance writer, blogger together with wandering spirit, mostly based inwards the Andalusian upper-case missive of the alphabet of Seville, Southern Spain. She is passionate virtually the healing potential of plants, inwards detail cannabis together with is currently invitee blogger for CBD crude innovators Endoca.
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